Inflammation in Chronic Disease

Inflammation is a normal process in the body involving activation of the immune system as a protective response to infection, irritation, and injury. However, in chronic disease, a process of repeated injury, inflammatory response, and immune system activation causes further injury. In this cycle, the body's normal protective mechanisms become destructive and central to progression of disease. This dysfunctional inflammation is involved in many chronic diseases.

At Naegis, our strategy is to discover new ways to treat chronic inflammatory diseases by blocking the cycle of injury and response. Our research team targets key enzymes in the cell that are involved in the synthesis of leukotrienes as well as intrinsic anti-inflammatory processes which mediate the recruitment of inflammatory cells, mucous production, edema, and other inflammatory events.

Serious chronic diseases that have a possible association with the function and products of these enzymes include:

  • Asthma
  • Allergic Rhinitis
  • COPD
  • Arthritis
  • Diabetes
  • Ocular Inflammation
  • Cardiovascular disease
  • Cancer
  • Idiopathic pulmonary fibrosis
  • Atopic Dermatitis
  • Sjogren-Larsson Syndrome

and many others...