What We Do

invertebratesNaegis Pharmaceuticals Inc. is an emerging biopharmaceutical company driven to discover new therapies that target the underlying chronic inflammation central to many diseases.  Through the discovery of novel small molecules that regulate key biochemical mechanisms, the company is committed to the goal of advancing new products that offer safe and more effective treatments for patients with serious debilitating conditions. Read More

Areas of Focus

testtubesInflammation is a normal process in the body, involving activation of the immune system as a protective response to infection, irritation, and injury. However, in chronic disease, a process of repeated injury, inflammatory response, and immune system activation causes further injury. In these cases therapeutic intervention may be the best way to address these debilitating conditions which include, among others, respiratory disease (e.g. asthma, COPD), neuroinflammatory disease (e.g. Alzheimer's Disease), and serious ocular conditions (e.g. uveitis, diabetic retinopathy). The Naegis research team seeks to design new medicines that offer safe and more effective treatment options for patients.
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bright flora 160 naegixEnzymes in the leukotriene pathway play critical roles, eliciting both pro-inflammatory and anti-inflammatory functions. As such, they serve as important biochemical targets for the discovery of new therapeutics. To date, the Naegis team has focused on two targets, 5-lipoxygenase (5-LO) and leukotriene-A4 hydrolase (LTA4H), Discovering small molecules that mediate the function of these enzymes is an important strategy that the company is undertaking in an effort to advanced drug candidates that may be safer and more effective than existing treatments.
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penguinsNaegis seeks to partner with organizations that share a like-mindedness and commitment to the discovery and development of important new therapies to address the needs of patients living with debilitating inflammatory diseases. In particular, the company is focused on the discovery of new therapies for COPD, a deteriorating respiratory condition with increasing rates of mortality, and for serious ocular inflammatory diseases, some of which may lead to blindness.

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